American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2021
Editorial CommentStress is in the Air: Ambient ROS and COVID-19.
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Am. J. Respir. Crit. Care Med. · Jul 2021
Multicenter StudySafety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis Associated Pulmonary Arterial Hypertension: A Multi-center, Double-blind, Randomized, Placebo-controlled Trial.
Rationale: Systemic sclerosis (SSc)-pulmonary arterial hypertension (PAH) is one of the most prevalent and deadly forms of PAH. B cells may contribute to SSc pathogenesis. Objectives: We investigated the safety and efficacy of B-cell depletion for SSc-PAH. ⋯ Conclusions: B-cell depletion therapy is a potentially effective and safe adjuvant treatment for SSc-PAH. Future studies in these patients can confirm whether the identified biomarkers predict rituximab responsiveness. Clinical trial registered with www.clinicaltrails.gov (NCT01086540).
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Am. J. Respir. Crit. Care Med. · Jul 2021
Historical ArticleLatent Tuberculosis: Two Centuries of Confusion.