American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2024
Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.
Chronic lung allograft dysfunction (CLAD) hinders lung transplant success. A 2019 consensus refined CLAD diagnosis, introducing probable or definite CLAD based on persistence of lung function decline. Outcomes and risks for probable CLAD remain uncertain. ⋯ Probable CLAD identifies patients at high risk for graft loss, supporting prospective identification of this condition for early initiation of CLAD-directed interventions. More effective strategies to prevent posttransplant cytomegalovirus, inhibit allospecific immunity, and reduce tissue injury are needed to reduce probable CLAD and improve lung recipient survival.
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Am. J. Respir. Crit. Care Med. · Oct 2024
Airway Mucus Plugs on Chest Computed Tomography Are Associated with Exacerbations in COPD.
Rationale/Objective: Acute exacerbations (AEs) of chronic obstructive pulmonary disease (COPD) are associated with significant morbidity and mortality. Whether mucus plugs are associated with prospective exacerbations has not been examined extensively. ⋯ CT-based mucus plugs are associated with an increased risk for future COPD AEs.