American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2024
Sex-specific Genetic Determinants of Right Ventricular Structure and Function.
While sex differences in right heart phenotypes have been observed, the molecular drivers remain unknown. ⋯ BMPR1A has emerged as a biologically plausible candidate gene for female-specific genetic determination of RV function, showing associations with cardiac performance under chronically increased afterload in female patients with PAH.
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Am. J. Respir. Crit. Care Med. · Oct 2024
Exploring Definitions and Predictors of Severe Asthma Clinical Remission Post-Biologic in Adults.
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving remission that may be used to predict it. ⋯ The odds of remission increased in those with fewer exacerbations per year, lower LTOCS daily dose, better control, and better lung function before biologic initiation. Conclusions: One in five patients achieved four-domain remission within 1 year of biologic initiation. Patients with less severe impairment and shorter asthma duration at initiation had a greater chance of achieving remission after biologic treatment, indicating that biologic treatment should not be delayed if remission is the goal.