Acta cardiologica
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Randomized Controlled Trial Comparative Study
Acute normovolaemic haemodilution with crystalloids in coronary artery bypass graft surgery: a preliminary survey of haemostatic markers.
Acute normovolaemic haemodilution (ANH) is a safe and cost-effective blood conservation strategy in procedures with great blood loss. It eliminates the risk of administrative errors and also contaminations that may occur whenever banked blood is used. Classically, haemodilution is regarded as causing coagulopathy. This study was designed to determine the effect of crystalloids on measured coagulation values and perioperative blood loss following ANH in patients undergoing elective coronary revascularization. ⋯ ANH reduced the need for PRBC and FFP by 58% and 74%, respectively. Regarding the increase in PT and decrease in Plt count, we concluded that performing ANH with saline solution (SS) in patients undergoing CABG surgery may cause a non-clinically significant change in coagulation state.