Croatian medical journal
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Croatian medical journal · Aug 2014
Multicenter Study Clinical TrialGastric band is safe and effective at three years in a national study subgroup of non-morbidly obese patients.
To analyze the 3-year outcomes of lower body mass index (BMI) (<35 kg/m2) adjustable gastric band (AGB) recipients across multiple sites in the French health insurance system. ⋯ In a retrospective analysis of a subgroup of BMI<35 kg/m2 patients, some following a prior bariatric procedure, SAGB was found to be safe and effective at 3-year follow-up.
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Croatian medical journal · Aug 2014
Editorial Biography Historical ArticleEnigma of cerebrospinal fluid dynamics.
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Croatian medical journal · Aug 2014
ReviewUpdate on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease.
Alzheimer disease (AD) is a complex neurodegenerative disorder, whose prevalence will dramatically rise by 2050. Despite numerous clinical trials investigating this disease, there is still no effective treatment. Many trials showed negative or inconclusive results, possibly because they recruited only patients with severe disease, who had not undergone disease-modifying therapies in preclinical stages of AD before severe degeneration occurred. ⋯ Hence, there is an urgent need for detection and validation of novel CSF biomarkers that would enable early diagnosis of AD in asymptomatic individuals. This article reviews recent research advances on biomarkers for AD, focusing mainly on the CSF biomarkers. In addition to core CSF biomarkers, the potential usefulness of novel CSF biomarkers is discussed.