Croatian medical journal
-
Croatian medical journal · Apr 2020
ReviewUse of pharmacogenomics in elderly patients treated for cardiovascular diseases.
Older people are increasingly susceptible to adverse drug reactions (ADRs) or therapeutic failure. This could be mediated by considerable polypharmacy, which increases the possibility of drug-drug and drug-gene interactions. Precision medicine, based on individual genetic variations, enables the screening of patients at risk for ADRs and the implementation of personalized treatment regimens. ⋯ Pharmacogenetics consortia have issued guidelines for oral anticoagulants, antiplatelet agents, statins, and some beta-blockers. Since the majority of pharmacogenetics recommendations are based on the assessment of single drug-gene interactions, it is imperative to develop tools for the prediction of multiple drug-drug-gene interactions, which are common in the elderly with comorbidity. The availability of genomic testing has grown, but its clinical application is still insufficient.
-
Croatian medical journal · Apr 2020
Review Historical Article"For aging not passively endured, but actively experienced:" on Symposium on Gerontology from 1958.
The subjects of gerontology and geriatrics did not arouse stronger interest among Croatian scholars until the second half of the twentieth century. From 1952 to 1957, a number of Croatian medical experts gave lectures on gerontology at the Yugoslav Academy of Sciences and Arts. ⋯ In this article, we focused on the contents of Symposium, namely, on the discussions about geriatric terminology, theories of aging, epistemological issues in gerontology, as well as clinical experiences with older patients. We argue that Symposium marks the beginning of a synthetic and interdisciplinary approach to gerontology in Croatia.