Croatian medical journal
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Croatian medical journal · Oct 2021
SIRT1 and Klotho expression in the heart and kidneys of rats with acute and chronic renovascular hypertension.
To evaluate Klotho and SIRT1 expression in the heart and kidneys of rats with acute and chronic renovascular hypertension. ⋯ Development of renovascular hypertension was associated with a reduction of SIRT1 expression in the heart and ischemic kidney. As angiotensin II and SIRT1 counteract each other's expression, a SIRT1 reduction in the heart and kidney, along with the influence of systemic/local angiotensin II, seems to be partly responsible for hypertension development. A combination of SIRT1 agonists and angiotensin II antagonists may be considered for use in the treatment of renovascular hypertension.
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Croatian medical journal · Oct 2021
Randomized Controlled TrialIntraoperative superior hypogastric plexus block for pain relief after a cesarean section: a case-control study.
To investigate the efficacy of intraoperative superior hypogastric plexus (SHP) block for postoperative pain relief in patients undergoing a cesarean section. ⋯ SHP block may be an effective and safe pain relief treatment after a cesarean section.
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Croatian medical journal · Oct 2021
Randomized Controlled Trial Observational StudyThe effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents.
To investigate whether three-month oral vitamin D supplementation (800 IU in drops) reduces the risk of influenza infection in elderly nursing home residents vaccinated against influenza. ⋯ Elderly nursing home residents in Zagreb County have a significant vitamin D deficiency. The recommended national supplementation of 800 IU daily failed to lead to vitamin D sufficiency and did not reduce the risk of influenza infection among the vaccinated elderly.
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Croatian medical journal · Oct 2021
Characteristics and clinical outcomes of patients with acute gastrointestinal bleeding related to anticoagulant or antiplatelet therapy: a retrospective study.
To investigate the demographic characteristics, endoscopic and laboratory findings, comorbidities and mortality rate of patients with gastrointestinal bleeding related to anticoagulant or antiplatelet therapy. ⋯ Although anticoagulant/antiplatelet therapy increases the risk of gastrointestinal bleeding, it does not directly affect the outcome, which is mainly determined by age and comorbidities.