Croatian medical journal
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Croatian medical journal · Dec 2021
Case ReportsInfliximab rescue therapy in a patient with acute severe ulcerative colitis and coronavirus disease 2019 followed by Escherichia coli 0157:H7 infection: a case report.
The management of patients with acute severe ulcerative colitis and SARS-CoV-2 presents a clinical challenge. We report on the first case of a patient with acute severe ulcerative colitis and mild coronavirus disease 2019 (COVID-19) who received rescue infliximab therapy, followed by a relapse caused by enterohemorrhagic Escherichia coli 0157:H7. The treatment challenges we faced were biologic therapy administration during active COVID-19, about which little was known at the time, and how to treat EHEC due to the risk of hemolytic uremic syndrome. ⋯ Our patient tested positive for SARS-CoV-2, but actually had mild disease. At the same time, she had acute severe ulcerative colitis, so we started anti-tumor necrosis factor therapy despite serological tests and the recommendation to delay biological therapy administration for two-weeks. Second, due to severity of the first flare, COVID-19, and the patient's general condition, we opted for an antibiotic treatment of Escherichia coli 0157:H7 while monitoring the parameters of potential hemolytic uremic syndrome development.
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Croatian medical journal · Oct 2021
Improving breast cancer prediction using a pattern recognition network with optimal feature subsets.
To predict the presence of breast cancer by using a pattern recognition network with optimal features based on routine blood analysis parameters and anthropometric data. ⋯ Breast cancer diagnosis was succesfully predicted using only five features. A model using a pattern recognition network with optimal feature subsets proposed in this study could be used to improve the early detection of breast cancer.