Acta clinica Croatica
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Acta clinica Croatica · Jun 2020
Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies.
The worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is used if suspicious cervical lymph nodes (LN) or thyroid bed masses are detected. Knowing that serum anti-Tg antibodies (sTgAb) affect the use of serum Tg (sTg) as a tumor marker, the aim of our study was to assess the usefulness of Tg determination in needle aspirates (FNA-Tg) in presence of sTgAb. This retrospective study included 149 patients with DTC and 159 aspirations of suspicious LN and thyroid bed masses. ⋯ Furthermore, we found a positive correlation between sTg and FNA-Tg levels (p<0.05), but not between sTgAb and FNA-TgAb or sTgAb and FNA-Tg. In conclusion, these results show that FNA-Tg values were not affected by sTgAb and that FNA-Tg measurement were highly effective in detecting cervical DTC metastases. However, combined use with cytology is suggested for neck evaluation because cytology could reveal metastases from other tumor sites.
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Acta clinica Croatica · Jun 2020
Hypocalcemia After Completion Thyroidectomy for Papillary Thyroid Carcinoma.
Surgical management of papillary thyroid carcinoma (PTC) includes total thyroidectomy and lobectomy. After lobectomy, a reoperation called completion thyroidectomy is occasionally required. Postoperative hypocalcemia is the most common complication associated with thyroid surgery. ⋯ However, these differences were not statistically significant. Every analyzed potential predictive factor was proven not to have any correlation with postoperative hypocalcemia. This study demonstrated that there was no significant difference between postoperative hypocalcemia rates in patients who underwent completion thyroidectomy compared with patients who underwent total thyroidectomy for PTC.
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Acta clinica Croatica · Jun 2020
Elective Central Compartment Lymph Node Dissection Does not Increase the Risk of Postoperative Hypoparathyroidism in Patients Treated for Differentiated Thyroid Cancer.
The aim of this study was to compare the incidence of postoperative hypoparathyroidism in two groups of patients who were treated for differentiated thyroid cancer. ⋯ Our results demonstrated that elective central compartment lymph node dissection is a safe procedure and does not significantly increase the risk of postoperative hypoparathyroidism when it is performed simultaneously with total thyroidectomy.
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Acta clinica Croatica · Jun 2020
The AsSociation Between Type 2 Diabetes Mellitus, Hypothyroidism, and Thyroid Cancer.
This study aimed to investigate the association between type 2 diabetes mellitus (T2DM), antidiabetic therapy, hypothyroidism, and thyroid cancer. We analyzed data from 320 patients who underwent thyroid surgery for suspicion of cancer. The diagnosis of thyroid cancer was confirmed by histopathological analysis in 95 patients. ⋯ Men with T2DM (OR, 6.19; 95% CI, 1.180-32.513) had higher prevalence of thyroid cancer than women. Patients who were on oral antidiabetics (OR, 1.91; 95% CI, 0.804-4.512) had higher prevalence of thyroid cancer than those receiving insulin. According to the results of this study, we can conclude that there is an association between T2DM, hypothyroidism, oral antidiabetics, and thyroid cancer.
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Acta clinica Croatica · Jun 2020
Voice Outcomes as a Results of Voice Therapy after Lobectomy and Thyroidectomy.
Voice disorders are among the most common complications of thyroid surgery. It is therefore advisable to continuously monitor and report the outcomes of voice rehabilitation among people who underwent thyroid surgery in order to recognize which specific clinical actions are necessary to give those patients the maximum chance to restore quality of life. ⋯ Multidimensional voice assessment using the GRBAS scale, Voice Handicap Index questionnaire, and acoustic analysis was carried out before and after voice therapy, which included relaxation and breathing exercises, laryngeal massage, resonance therapy, and the employment of the digital compression method. Since the Wilcoxon Signed Ranks Test showed significant improvements in all voice parameters after voice therapy, voice rehabilitation seems to be the essential clinical activity for thyroid surgery patients who suffer from voice disorders postoperatively.