Arthritis and rheumatism
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Arthritis and rheumatism · Nov 1999
Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region.
To analyze the genotypes of the promoter region of the serotonin transporter gene (5-HTT) in patients with fibromyalgia (FM). ⋯ A higher frequency of the S/S genotype of 5-HTT was found in FM patients compared with healthy controls. The S/S subgroup exhibited higher mean levels of depression and psychological distress. These results support the notion of altered serotonin metabolism in at least a subgroup of patients with FM.