Arthritis and rheumatism
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Arthritis and rheumatism · Sep 2007
Randomized Controlled Trial Multicenter StudyA randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis.
To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid arthritis (JRA). ⋯ While infliximab at 3 mg/kg and 6 mg/kg showed durable efficacy at 1 year, achievement of the primary efficacy end point at 3 months did not differ significantly between infliximab-treated and placebo-treated patients. Safety data indicated that the 6-mg/kg dose may provide a more favorable risk/benefit profile. These results warrant further investigation in children with JRA.