Arthritis and rheumatism
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Arthritis and rheumatism · Aug 2010
Randomized Controlled Trial Multicenter StudyAdalimumab in severe and acute sciatica: a multicenter, randomized, double-blind, placebo-controlled trial.
Based on several experimental results and on a preliminary study, a trial was undertaken to assess the efficacy of adalimumab, a tumor necrosis factor alpha inhibitor, in patients with radicular pain due to lumbar disc herniation. ⋯ The addition of a short course of adalimumab to the treatment regimen of patients experiencing acute and severe sciatica resulted in a small decrease in leg pain and in significantly fewer surgical procedures.
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Arthritis and rheumatism · Aug 2010
Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity.
Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients. The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain. ⋯ These findings indicate that resting brain activity within multiple networks is associated with spontaneous clinical pain in patients with FM. These findings may also have broader implications for how subjective experiences such as pain arise from a complex interplay among multiple brain networks.