Arthritis and rheumatism
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Arthritis and rheumatism · May 2013
Normalization of widespread pressure pain hypersensitivity after total hip replacement in patients with hip osteoarthritis is associated with clinical and functional improvements.
To evaluate the relevance of ongoing nociceptive joint inputs to the maintenance of widespread pain hypersensitivity in patients with hip osteoarthritis (OA) and to determine whether a reversal in the widespread pressure hypersensitivity together with an improvement in pain and function occurs after total hip replacement in these patients. ⋯ Normalization of widespread pressure pain hyperalgesia was found after successful hip joint replacement in patients with hip OA. Altered pain processing seems to be driven by ongoing peripheral joint pathology, which stresses the importance of reducing pain in OA.
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Arthritis and rheumatism · May 2013
Which patients are most likely to benefit from total joint arthroplasty?
To evaluate patient predictors of good outcome following total joint arthroplasty (TJA). ⋯ In an OA cohort with a high prevalence of multiple troublesome joints and comorbidity, only half achieved a good TJA outcome, defined as improved pain and disability. A more comprehensive assessment of the benefits and risks of TJA is warranted.
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Arthritis and rheumatism · May 2013
Brief report: incidence of selected opportunistic infections among children with juvenile idiopathic arthritis.
To compare incidence rates of selected opportunistic infections among children with and children without juvenile idiopathic arthritis (JIA). ⋯ Opportunistic infections are rare among children with JIA. Nevertheless, children with JIA had a higher rate of opportunistic infections, including an increased rate of Coccidioides, Salmonella, and herpes zoster compared to children with ADHD.
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Arthritis and rheumatism · May 2013
Analgesic effect of the neuropeptide cortistatin in murine models of arthritic inflammatory pain.
To investigate the role of the antiinflammatory neuropeptide cortistatin in chronic pain evoked by joint inflammation. ⋯ These findings indicate that cortistatin is an antiinflammatory factor with potent analgesic effects that may offer a new approach to pain therapy in pathologic inflammatory states, including osteoarthritis and rheumatoid arthritis.