Journal of gastroenterology
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Does long-term medication with a proton pump inhibitor induce a tolerance to H2 receptor antagonist?
Previous reports suggest that complete tolerance to H2 receptor antagonists (H2RAs) in patients with regular H2RA medication may be due to hypergastrinemia-increased histamine synthesis or upregulation of H2 receptors. As proton pump inhibitors (PPIs) have been reported to induce hypergastrinemia (similar to H2RAs), patients receiving long-term medication with PPIs may show tolerance to preanesthetic H2RA. Therefore, we studied the efficacy of an H2RA, roxatidine, in patients receiving long-term PPI medication. ⋯ These data suggest that long-term PPI medication may not induce a tolerance to H2RAs.