Journal of gastroenterology
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Multicenter Study Clinical Trial
Repeated administration of recombinant human serum albumin caused no serious allergic reactions in patients with liver cirrhosis: a multicenter clinical study.
We carried out a multicenter study to evaluate the safety of recombinant human serum albumin (rHSA), developed using the methylotrophic yeast Pichia pastoris, during and after repeated administration in patients with liver cirrhosis. ⋯ rHSA caused no serious allergic reactions even when three treatment courses were administered at intervals of at least 2 weeks.