Journal of gastroenterology

The most recent articles from: J. Gastroenterol. August 2017

J. Gastroenterol. · Aug 2017

Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis.

Nonalcoholic fatty liver disease ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). Kupffer cells play a central role in promoting hepatic inflammation, which leads to the development of NASH. We investigated the anti-inflammatory effect of hepatic vagus-mediated stimulation of the α7 nicotinic acetylcholine receptor (α7nAChR) on Kupffer cells in NASH pathogenesis. ⋯ Hepatic vagus activity regulates the inflammatory response of Kupffer cells via α7nAChR in NASH development.

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