Australian dental journal
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Australian dental journal · Dec 2006
Randomized Controlled TrialEfficacy of pilocarpine lozenge for post-radiation xerostomia in patients with head and neck cancer.
Patients with radiation-induced xerostomia produce little or no saliva. Several studies have demonstrated the efficacy of systemic administration of pilocarpine hydrochloride in individuals with post-radiation xerostomia. However, analysis of pilocarpine lozenges for treatment of post-radiation xerostomia in patients with head and neck cancer has not been reported. ⋯ The 5-mg pilocarpine lozenge produced the best clinical results, but further investigation with a larger group of patients is required.