Acta dermatovenerologica Croatica : ADC
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Acta Dermatovenerol Croat · Jul 2020
Review Historical ArticleSyphilis and Pharmaceutical Industry Marketing Between the Two World Wars in Croatia.
Between the two World Wars, the pharmaceutical industry strengthened its influence within the Croatian medical community. Due to the scarcity of professional biomedical journals in the Croatian language, larger pharmaceutical companies started to publish free promotional journals, magazines, and booklets which quickly became popular. They thus succeeded in creating a broad network of opinion leaders by recruiting physicians as authors, primarily writing on their experiences with application of certain drugs. As a paradigmatic social disease of the interwar period, syphilis stimulated the development of various marketing strategies used by the industry in these publications.
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Acta Dermatovenerol Croat · Jul 2020
LetterExpression of p16 Protein in Cutaneous Basal Cell Carcinoma: Still far from Being Clearly Understood.
Dear Editor, p16INK4a protein (p16) is an important tumor suppressor protein involved in the carcinogenesis of many human malignancies. I have read with interest an article by Donati et al. (1) in this journal, who investigated an expression of p16 and proliferation marker Ki-67 in cutaneous tumors. Among them, there were 27 cases of non-melanoma skin cancer (NMSC), 23 of which comprised basal cell carcinoma (BCC), and 4 squamous cell carcinoma (SCC) lesions. ⋯ Taken together, the biologic and clinical aspects of p16 production in cutaneous BCC are still far from being clearly understood. I assume that a simple quantification of p16 expression in BCC by immunohistochemistry is not sufficient for a reliable assessment of the clinicopathologic significances. Further studies must be more focused on spatial distribution and intensity of p16-positive areas in tumor tissue.