Expert opinion on investigational drugs
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Expert Opin Investig Drugs · Jul 2010
ReviewProgesterone in the clinical treatment of acute traumatic brain injury.
Traumatic brain injury (TBI) has yet to find a safe and effective acute-stage neuroprotective treatment. Experimental drugs targeting a single receptor mechanism, gene, or brain locus have failed. ⋯ The idea that PROG is just a female reproductive hormone is outdated. We propose that PROG has substantial pleiotropic properties as a neuroprotective agent in a variety of CNS injury models.
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Expert Opin Investig Drugs · Jul 2010
ReviewCalcitonin gene-related peptide receptor antagonists for migraine.
Migraine is a highly prevalent disabling condition, and the current treatment options are not satisfactory. The role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology is well established. CGRP receptor antagonists address this new target and have the potential to improve therapy for both responders and non-responders to previous options. ⋯ CGRP receptor antagonists will provide an additional and valuable therapeutic option for the treatment of headaches.