Expert opinion on investigational drugs
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Expert Opin Investig Drugs · Oct 2011
The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs.
DepoFoam bupivacaine (DB) is in development for prolonged postoperative analgesia. Studies were conducted to evaluate the potential local and systemic toxicity and any effect on wound healing after wound infiltration. ⋯ The data reported here are the first demonstration of the safety of DB in toxicology species.