Microcirculation : the official journal of the Microcirculatory Society, Inc
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Increased morbidity and mortality in critically ill obese patients may result from an exaggerated inflammatory response and/or a diminished effectiveness of routine therapeutic strategies used in the critical care setting. The objectives of this study were to compare the effectiveness of hypertonic saline (HTS) resuscitation in obese and lean mice with sepsis and to address potential mechanisms underlying HTS-mediated protection against the inflammatory and microvascular responses to sepsis. ⋯ HTS exerts significant anti-inflammatory and anti-thrombogenic actions in obese septic mice. These responses may be related to the inhibitory effect of HTS on sepsis-induced P-selectin expression.