British journal of cancer
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British journal of cancer · Jan 2017
Multicenter Study Clinical TrialOrgan preservation with local excision or active surveillance following chemoradiotherapy for rectal cancer.
Organ preservation has been proposed as an alternative to radical surgery for rectal cancer to reduce morbidity and mortality, and to improve functional outcome. ⋯ Organ preservation for locally advanced rectal cancer is feasible for selected patients who achieve an objective endoluminal response to neoadjuvant CRT. Transanal excision defines the pathological response and refines decision-making.