Phytomedicine : international journal of phytotherapy and phytopharmacology
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Tenuigenin (TEN), a natural product from the Chinese herb Polygala tenuifolia root, has been reported to improve cognitive function and exhibits neuroprotective effects in pharmacological studies of the central nervous system. Synaptic transmission is the essential process of brain physiological functions such as learning and memory formation, and TEN has been shown to facilitate the basic synaptic transmission. ⋯ These results indicate that TEN enhances the basic synaptic transmission via stimulating presynaptic intracellular calcium.