Phytomedicine : international journal of phytotherapy and phytopharmacology
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Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects. ⋯ There are numerous results reporting on the anti-trypanosomal activity the genus Artemisia, artemisinin and its derivatives and other phytochemicals from Artemisia species. This field of research is, however, still in its infancy and more intensive research is required to explore the full potential of diverse Artemisia species and their chemical ingredients for eradication of trypanosomal infections.
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Current quality control methods for traditional Chinese patent medicines (TCPMs), e.g., microscopy, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC), cannot detect herbal species composition with adequate precision. To address this issue, more effective detection methods should be explored. ⋯ The results highlight that shotgun metagenomic sequencing is a complementary method for the precise species detection of TCPMs.