Journal of computational neuroscience
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The temperature-frequency relationship in nerve conduction block induced by high-frequency, biphasic electrical current was investigated by computer simulation using an amphibian myelinated axon model based on Frankenhaeuser-Huxley (FH) equations. For an axon of diameter 10 microm, the minimal blocking frequency was changed from 6 to 3 kHz as the temperature was decreased from 37 degrees C to 15 degrees C. ⋯ Simulation analysis also revealed that activation of potassium channels might determine the temperature-frequency relationship. This study indicates that temperature might be one of the factors that cause the frequency discrepancy as reported in previous animal studies.