American journal of therapeutics
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Clinical Trial
Nicardipine to control mean arterial pressure after cardiothoracic surgery in infants and children.
Nicardipine is the first intravenously administered dihydropyridine calcium channel blocker. Its primary physiologic action includes vasodilatation with limited effects on the inotropic and dromotropic function of the myocardium. Several previous reports document its use in adult patients for pharmacologic control of blood pressure. ⋯ In the nine patients, nicardipine was infused for a total of 337 hours. No adverse effects such as excessive hypotension were noted. Nicardipine is an effective agent for controlling MAP after cardiothoracic surgical procedures in infants and children.