Journal of cardiac failure
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Randomized Controlled Trial Clinical Trial
Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure.
Parasympathetic dysfunction is an independent risk factor for mortality in heart failure for which there is no specific pharmacologic treatment. This article aims to determine the effect of pyridostigmine, an anticholinesterase agent, on the integrated physiologic responses to dynamic exercise in heart failure. ⋯ Pyridostigmine was well tolerated by heart failure patients, leading to improved hemodynamic profile during dynamic exercise.