Haemophilia : the official journal of the World Federation of Hemophilia
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Multicenter Study Clinical Trial
Once-weekly prophylactic treatment vs. on-demand treatment with nonacog alfa in patients with moderately severe to severe haemophilia B.
Limited data are available on optimal prophylaxis regimens of factor IX (FIX) replacements for patients with haemophilia B. ⋯ Once-weekly prophylaxis of 100 IU kg(-1) was associated with lower ABR compared with on-demand treatment in adolescents and adults with moderately severe to severe haemophilia B. Once-weekly prophylaxis was well tolerated, with a similar safety profile as that reported during the on-demand treatment period. Residual FIX:C may be supportive of effectiveness.