Journal of investigative medicine : the official publication of the American Federation for Clinical Research
-
We assessed the effect of a cytokine inhibitor, compound SKF 86002 (a bicyclic imidazole), on changes in renal hemodynamics (renal blood flow and glomerular filtration rate) that occur acutely following immune injury of glomerular mesangial cells. ⋯ The observations indicate that in mesangial cell immune injury, cytokines mediate renal hemodynamic impairment.