Journal of investigative medicine : the official publication of the American Federation for Clinical Research
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The polymorphisms within the FTO gene play an important role in the genetic determination of body weight and body mass index and have been associated with cardiovascular disease, but the causal mechanism is still a matter of debate. The possible effect on the platelet count as a marker of hemocoagulation status as a possible cardiovascular risk factor was suggested in Japanese population. ⋯ We have not detected a significant association between the FTO rs1558902 variant and platelet counts in white women (TT, 242 ± 55 × 10; TA, 246 ± 67 × 10; and AA, 247 ± 55 × 10; F[2.642] = 0.30, P = 0.75). At least in white persons, platelet count seems not to be a link between the FTO variation and risk of cardiovascular disease.
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Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin resistant. The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on metabolic response, weight loss, and serum leptin levels to a high monounsaturated fat hypocaloric diet in obese patients. ⋯ Patients with Asn656 allele have a different response than Lys656Lys genotype subjects, with a lack of decrease in insulin levels, leptin levels, and homeostasis model assessment of insulin resistance after weight loss.