Journal of investigative medicine : the official publication of the American Federation for Clinical Research
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Randomized Controlled Trial
Effect of bromhexine in hospitalized patients with COVID-19.
Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial. ⋯ Bromhexine is not an effective treatment for hospitalized patients with COVID-19. The potential prevention benefits of bromhexine in asymptomatic postexposure or with mild infection managed in the community remain to be determined.