Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Randomized Controlled Trial Multicenter Study Clinical TrialRandomised controlled trial evaluating effects of morphine on plasma adrenaline/noradrenaline concentrations in newborns.
To determine the effects of continuous morphine infusion in ventilated newborns on plasma concentrations of adrenaline (epinephrine) and noradrenaline (norepinephrine) and their relation to clinical outcome. ⋯ Continuous morphine infusion significantly decreased plasma noradrenaline concentrations in ventilated newborns compared with placebo treatment. The results of this study support the idea that routine morphine administration decreases stress responses in ventilated neonates.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Randomized Controlled Trial Clinical TrialObtaining pulse oximetry data in neonates: a randomised crossover study of sensor application techniques.
Pulse oximetry may be useful during neonatal resuscitation. A randomised crossover study was performed to determine the most efficient method of applying the sensor. Applying it to the infant before connecting to the oximeter resulted in quickest acquisition of accurate heart rate. This technique should be preferred during resuscitation.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Multicenter StudyBenefit of antenatal glucocorticoids according to the cause of very premature birth.
In this observational study performed in a large cohort of very preterm singletons, respiratory outcome was found to be strongly dependent on the cause of premature delivery. Although less apparent in infants born to mothers with chorioamnionitis, exposure to antenatal glucocorticoids remained significantly associated with a decrease in the incidence of respiratory distress syndrome after adjustment for the main cause of premature birth.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Respiratory function monitoring during neonatal emergency transport.
This study reports for the first time the use of a respiratory function monitor in a prospective observational cohort of ventilated babies during transport. All 17 babies achieved target transcutaneous carbon dioxide tension within 15 minutes. Fifteen babies had improved ventilation with changes guided by the respiratory function monitor. The monitor was easy to use and useful.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?
Episodes of hyperoxaemia and hypocapnia, which may contribute to brain injury, occur unintentionally in severely asphyxiated neonates in the first postnatal hours. ⋯ Severe hyperoxaemia and severe hypocapnia were associated with adverse outcome in infants with post-asphyxial HIE. During the first hours of life, oxygen supplementation and ventilation should be rigorously controlled.