Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · May 2010
Changes in heart rate in the first minutes after birth.
The normal range of heart rate (HR) in the first minutes after birth has not been defined. Objective To describe the HR changes of healthy newborn infants in the delivery room (DR) detected by pulse oximetry. Study Design All inborn infants were eligible and included if a member of the research team attended the birth. ⋯ Conclusions The median HR was <100 bpm at 1 min after birth. After 2 min it was uncommon to have a HR <100 bpm. In preterm infants and those born by caesarean section the HR rose more slowly than term vaginal births.
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Arch. Dis. Child. Fetal Neonatal Ed. · May 2010
Regional tissue oxygenation in association with duration of hypoxaemia and haemodynamic variability in preterm neonates.
To assess the effect of the duration of spontaneous hypoxic episodes and variations in haemodynamic parameters on cerebral and renal tissue oxygenation (rSo(2)C and rSo(2)R) in clinically stable preterm infants. ⋯ Prolongation of hypoxaemia contributes to the severity of the deoxygenation (systemic and regional) and development of bradycardia. In stable preterm neonates, mild decreases in MBP independently affect the renal but not cerebral tissue oxygenation and oxygen utilisation.
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Arch. Dis. Child. Fetal Neonatal Ed. · Mar 2010
Randomized Controlled TrialRemifentanil for endotracheal intubation in neonates: a randomised controlled trial.
To evaluate the efficacy and safety of remifentanil as a premedication in neonates undergoing elective endotracheal intubation. ⋯ Although remifentanil is comparable to fentanyl and succinylcholine in attenuating adverse physiologic responses during neonatal intubation, muscle rigidity is a concern at doses of 3 microg/kg. Further trials are required to evaluate ideal dosing regimens and combinations of agents for use with remifentanil in neonates.
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Arch. Dis. Child. Fetal Neonatal Ed. · Mar 2010
Randomized Controlled TrialNasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomised control trial.
To evaluate the clinical course, respiratory outcomes and markers of inflammation in preterm infants with moderate respiratory distress syndrome (RDS) assigned from birth to nasal continuous positive airway pressure (NCPAP) or bi-level NCPAP. ⋯ Bi-level NCPAP was associated with better respiratory outcomes versus NCPAP, and allowed earlier discharge, inducing the same changes in the cytokine levels. It was found to be well tolerated and safe in the study population.
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Arch. Dis. Child. Fetal Neonatal Ed. · Mar 2010
Antenatal corticosteroids and neonatal outcomes according to gestational age: a cohort study.
To see whether there was any difference in the effect of antenatal corticosteroids on neonatal outcomes according to different gestational ages at birth. ⋯ Antenatal corticosteroid treatment is associated with improved survival in babies born between 24 and 29 weeks' gestation. This, however, does not lead to any significant improvements in length of stay, duration of respiratory support and CLD among survivors.