Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 1999
Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates.
To investigate the pharmacokinetics, metabolism, and dose-response relation of a single rectal dose of paracetamol in preterm infants in two different age groups. ⋯ A 20 mg/kg single dose of paracetamol can be safely given to preterm infants in whom sulphation is the major pathway of excretion. Multiple doses in 28-32 week old neonates would require an interval of more than 8 hours to prevent progressively increasing serum concentrations.
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Arch. Dis. Child. Fetal Neonatal Ed. · Nov 1998
Randomized Controlled Trial Clinical TrialRandomised controlled trial of paracetamol for heel prick pain in neonates.
To evaluate the effectiveness of paracetamol in decreasing the pain from heel prick. ⋯ Paracetamol is ineffective for decreasing the pain from heel prick in term neonates.
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Arch. Dis. Child. Fetal Neonatal Ed. · Sep 1998
Randomized Controlled Trial Comparative Study Clinical TrialRandomised crossover trial of salbutamol aerosol delivered by metered dose inhaler, jet nebuliser, and ultrasonic nebuliser in chronic lung disease.
To compare the efficacy of salbutamol delivered by metered dose inhaler (MDI), jet nebuliser, and ultrasonic nebuliser in ventilated infants with chronic lung disease. ⋯ These findings suggest that among the devices tested, the delivery of salbutamol aerosol to the lower respiratory tract was greatest using the ultrasonic nebuliser, and least with the jet nebulisers.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jul 1998
Outcome at 5-6 years of prematurely born children who received morphine as neonates.
To assess outcome at 5-6 years in a cohort of very preterm infants (< 34 weeks of gestation) who had been randomly allocated within a controlled clinical trial to receive morphine or non-morphine treatment in the neonatal period. ⋯ Exposure to morphine in the neonatal period to facilitate mechanical ventilation does not seem to have any adverse effects on intelligence, motor function, or behaviour when these children are assessed at 5-6 years of age.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jul 1998
Randomized Controlled Trial Comparative Study Clinical TrialRandomised, controlled trial of nasal continuous positive airway pressure in the extubation of infants weighing 600 to 1250 g.
To determine whether extubation to nasal continuous airway pressure (NCPAP) results in a greater proportion of infants remaining free of additional ventilatory support for one week after extubation compared with those extubated directly to headbox oxygen. ⋯ NCPAP applied prophylactically after endotracheal extubation reduces the incidence of adverse clinical events that lead to failure of extubation in the seven days after extubation. This reduction is clinically important. The benefits of NCPAP do not seem to be associated with an increased incidence of unwanted side effects.