Journal of thrombosis and thrombolysis
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J. Thromb. Thrombolysis · Jun 2002
Multicenter Study Clinical TrialFeasibility and timing of prehospital administration of reteplase in patients with acute myocardial infarction.
In myocardial infarction patients undergoing thrombolysis, treatment delays negatively impact outcomes. This pilot study was conducted to determine the feasibility and timing of field administration of intravenous double bolus reteplase in patients with ST-elevation myocardial infarction. ⋯ These results demonstrated that in-field administration of thrombolytic therapy is a viable option to reduce the delay from symptom onset to initiation of thrombolysis. They demonstrated that satisfactory resolution of ST-segment elevation can be recorded in the field. The reduction in mortality observed in this study is comparable to previously published studies on inpatients.