Journal of thrombosis and thrombolysis
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J. Thromb. Thrombolysis · May 2009
Comparative StudyAspirin is insufficient in inhibition of platelet aggregation and thromboxane formation early after coronary artery bypass surgery.
Aspirin administered early after coronary artery bypass grafting surgery (CABG) improves graft patency and patients survival. However, the antiplatelet effect of aspirin seems to be variable and aspirin resistance is currently still being discussed. The aim of the study was to assess aspirin efficacy in the early postoperative period. ⋯ Aspirin did not sufficiently inhibit platelet aggregation and thromboxane formation in the early postoperative period. Thus, antiplatelet treatment strategy should be intensified or modified in patients early after bypass surgery.