The journals of gerontology. Series A, Biological sciences and medical sciences
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J. Gerontol. A Biol. Sci. Med. Sci. · Jul 2014
Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.
A substantial proportion of the general population has low lung function, and lung function is known to decrease as we age. Low lung function is a feature of several pulmonary disorders, such as uncontrolled asthma and chronic obstructive pulmonary disease. The objective of this study is to investigate the association of polymorphisms in asthma and chronic obstructive pulmonary disease candidate genes with rates of lung function decline in a general population sample of aging men. ⋯ Our findings that genetic variants of genes involved in asthma and chronic obstructive pulmonary disease are associated with lung function decline in normal aging participants suggest that similar genetic mechanisms may underlie lung function decline in both disease and normal aging processes.
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J. Gerontol. A Biol. Sci. Med. Sci. · Jul 2014
Dietary patterns and incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 study.
To date, little is known about the association between dietary pattern and disability in older adults. The present prospective cohort study investigated the association between dietary patterns and incident functional disability. ⋯ In Japanese older persons, the Japanese dietary pattern is associated with a decreased risk of incident functional disability.