The journals of gerontology. Series A, Biological sciences and medical sciences
-
J. Gerontol. A Biol. Sci. Med. Sci. · Jan 2019
Multicenter StudyAssociation of Trajectories of Higher-Level Functional Capacity with Mortality and Medical and Long-Term Care Costs Among Community-Dwelling Older Japanese.
Higher-level functional capacity is crucial component for independent living in later life. We used repeated-measures analysis to identify aging trajectories in higher-level functional capacity. We then determined whether these trajectories were associated with all-cause mortality and examined differences in medical and long-term care costs between trajectories among community-dwelling older Japanese. ⋯ People with a low-decreasing aging trajectory in higher-level functional capacity had higher risks of death and had high monthly total costs.
-
J. Gerontol. A Biol. Sci. Med. Sci. · Jan 2019
Multicenter StudyDevelopment of a Dynamic Multi-Protein Signature of Postoperative Delirium.
Delirium is common, morbid, and costly, yet its biology is poorly understood. We aimed to develop a multi-protein signature of delirium by identifying proteins associated with delirium from unbiased proteomics and combining them with delirium biomarkers identified in our prior work (interleukin [IL]-6 and IL-2). ⋯ The signature of postoperative delirium is dynamic, with some proteins important before surgery (risk markers) and others at the time of delirium (disease markers). Our dynamic, multi-protein signature for delirium improves our understanding of delirium pathophysiology and may identify patients at-risk of this devastating disorder that threatens independence of older adults.