The American journal of orthopedics
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Intravenous parecoxib sodium foracute pain after orthopedic knee surgery.
Our objective in a randomized, multicenter, double-blind, parallel-group, placebo- and active-controlled study was to evaluate and compare the analgesic effectiveness of single intravenous (IV) doses of parecoxib sodium 20 and 40 mg, morphine 4 mg, and ketorolac 30 mg in the postsurgical orthopedic pain model. After undergoing unilateral total knee replacement surgery, 208 healthy adult patients were randomized to receive placebo or a study drug within 6 hours of discontinuation of patient-controlled analgesia on postoperative day 1. ⋯ Parecoxib sodium was safe and well tolerated. In conclusion, IV parecoxib sodium 40 mg is as effective as ketorolac 30 mg and is more effective than morphine 4 mg and therefore has potential widespread utility in acute postoperative pain management.
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The purpose of this study was to determine the publication rates of presentations made at the annual meetings of 2 sports medicine specialty societies--the American Orthopaedic Society for Sports Medicine (AOSSM) and the Arthroscopy Association of North America (AANA). We created a database covering annual AOSSM meetings from 1990 to 1993 (4 years) and annual AANA meetings from 1991 to 1993 (3 years) and searched the Melvyl Medline Plus database for abstracts from 1990 through 1998 to determine which had been published in peer-reviewed journals. ⋯ The majority of articles were published in American Journal of Sports Medicine (40.1%) and Arthroscopy (30.3%). Publication rates of presentations made at meetings of these sports medicine specialty societies are high and exceed the publication rates associated with meetings of other medicine specialty societies.