American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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Am J Health Syst Pharm · May 1996
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
The compatibility of lyophilized thiotepa injection with selected other drugs during simulated Y-site injection was evaluated. Five-milliliter samples of thiotepa (lyophilized) 1 mg/mL in 5% dextrose injection were combined with 5 mL each of 100 other drugs, including antineoplastics, anti-infectives, and supportive care drugs, in 5% dextrose injection or 0.9% sodium chloride injection. The combinations were stored at room temperature (approximately 23 degrees C) under constant fluorescent light. ⋯ Two drugs exhibited incompatibilities with thiotepa. The thiotepa-cisplatin combination developed turbidity in four hours, and the thiotepa-minocycline hydrochloride combination developed a bright yellow-green discoloration in one hour. All the test drugs except cisplatin and minocycline hydrochloride were compatible with thiotepa 1 mg/mL (prepared from the lyophilized formulation) for at least four hours at room temperature.