American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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Am J Health Syst Pharm · Mar 2012
Case ReportsSuccessful desensitization to docetaxel after severe hypersensitivity reactions in two patients.
Two cases of successful desensitization to docetaxel after severe hypersensitivity reactions are reported. ⋯ Two patients who had severe hypersensitivity reactions to docetaxel successfully received further docetaxel doses via a desensitization procedure that involved the sequential administration of solutions containing increasing concentrations of the drug.
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Am J Health Syst Pharm · Mar 2012
ReviewPreventing venous thromboembolism in hospitalized patients with cancer: improving compliance with clinical practice guidelines.
The use of anticoagulants for the prevention of venous thromboembolism (VTE) in hospitalized medical and surgical oncology patients is discussed. ⋯ Hospitalized patients with cancer often do not receive appropriate thromboprophylaxis. Guidelines from ASCO, ACCP, and NCCN recommend unfractionated heparin, an LMWH, or fondaparinux for VTE prophylaxis when there are no contraindications to such therapy.
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Am J Health Syst Pharm · Mar 2012
ReviewThe role of mucoregulatory agents after continence-preserving urinary diversion surgery.
The postsurgical use of N-acetylcysteine, octreotide, and other agents to reduce mucus accumulation after urinary diversion procedures is described. ⋯ Various agents evaluated for mucus control after urinary diversion procedures (oral ranitidine or aspirin, N-acetylcysteine or urea instillations, and subcutaneous octreotide), while reportedly effective for some patients, remain of questionable benefit. More research is needed to define the optimal role of these agents for this indication.