American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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Am J Health Syst Pharm · Sep 2015
Survey of career satisfaction, lifestyle, and stress levels among pharmacy school faculty.
U.S. pharmacy school faculty were surveyed to assess their career satisfaction, lifestyle, and stress levels. ⋯ A survey of pharmacy faculty in the United States revealed high levels of job satisfaction among respondents, but lower levels of satisfaction with work-life balance and comparable levels of stress to the general population were found. Administrators and stakeholders should explore options to improve lifestyle factors to decrease potential burnout among faculty.
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Am J Health Syst Pharm · Sep 2015
ReviewPathophysiology, assessment, and management of pain in critically ill adults.
The pathophysiology of pain in critically ill patients, the role of pain assessment in optimal pain management, and pharmacologic and nonpharmacologic strategies for pain prevention and treatment are reviewed. ⋯ Acute pain management in the critically ill is a largely underassessed and undertreated area of critical care. Opioids are the cornerstone of treatment, though a multimodal approach may improve patient outcomes and decrease opioid-related adverse events.
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Am J Health Syst Pharm · Sep 2015
Review Comparative StudyRole of anaplastic lymphoma kinase inhibition in the treatment of non-small-cell lung cancer.
Published data on the clinical efficacy, safety, dosage and administration, and costs of the anaplastic lymphoma kinase (ALK) inhibitors crizotinib and ceritinib in the treatment of non-small-cell lung cancer (NSCLC) are reviewed and compared. ⋯ The tyrosine kinase inhibitors crizotinib and ceritinib provide an effective treatment approach for patients with ALK-mutated NSCLC. Efficacy data for both crizotinib and ceritinib indicate improved response rates and PFS with the use of either drug as an alternative to standard chemotherapy.
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Am J Health Syst Pharm · Sep 2015
Conversion from thrice- to twice-daily pregabalin dosing for pain: Economic and clinical outcomes in a veteran population.
Results of a study analyzing economic and clinical outcomes one year after conversion from thrice- to twice-daily pregabalin dosing for pain are presented. ⋯ In patients receiving pregabalin for pain, conversion from thrice- to twice-daily pregabalin dosing-while maintaining the same daily dose-resulted in substantial cost savings while having little effect on clinical outcomes.