American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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The flow rate accuracy and flow continuity of the Homepump, Infusor, Intermate, Paragon, Sidekick, and Springfusor 10 flow-restricting infusion devices were studied. Three of each device were tested in a temperature-controlled cabinet at the manufacturer-specified operating temperature and at 20 and 30 degrees C. The flow rates used were 100 ml/hr and the rate that would provide a 24-hour delivery of fluid, except in the case of the Springfusor 10, which was tested at the maximum and minimum flow rates. ⋯ The definition of the endopoint made little difference in the flow rate results for the Infusor and Springfusor 10 but significantly affected the flow rate results for the other devices, for which there was a substantial terminal phase with a prolonged period of reduced flow rate. The mean flow rate, error, and coefficient of variation for the Intermate devices stored under refrigeration were significantly different from those for the devices not refrigerated before use. When operated as recommended by the manufacturer, five of six devices had a flow rate error within the manufacturer's specifications; the results were affected by endpoint definition.
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Am J Health Syst Pharm · Jan 1998
Stability of reconstituted indomethacin sodium trihydrate in original vials and polypropylene syringes.
The stability of reconstituted indomethacin sodium trihydrate 0.5 mg/mL in sterile water for injection for 14 days at either 2-6 degrees C or room temperature (21-25 degrees C) in the drug's original vial and in polypropylene syringes was studied. Twenty 1-mg vials of indomethacin sodium trihydrate were reconstituted with 2 mL of Sterile Water for Injection, USP. Solution from 10 vials was drawn into 20 1-mL disposable polypropylene syringes. ⋯ Solutions stored at room temperature in either syringes or vials had greater amounts of degradation products than solutions stored at 2-6 degrees C. Reconstituted indomethacin sodium trihydrate 0.5 mg/mL was stable for 14 days when stored in polypropylene syringes at 2-6 or 21-25 degrees C and in its original glass vials at 2-6 degrees C. When stored in the glass vials at 21-25 degrees C, the reconstituted drug was stable for 12 days.