Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Apr 2004
Randomized Controlled Trial Comparative Study Clinical TrialImmune and histopathologic examination of flea bite-induced papular urticaria.
Papular urticaria caused by flea bite presents clinical symptoms of hypersensitive reaction accompanied by skin lesions. Diagnostic and therapeutic approaches to the disease often go unrewarded, partly because of our incomplete understanding of the underlying immunopathogenesis. ⋯ Our results suggest that the clinical manifestations of papular urticaria are mediated by a complex immune response involving more than one mechanism, with evidence forboth an IgE response and a cell-mediated type IV response.