Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
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In chronic wounds, biofilms probably play a vital role in protecting bacteria from host defenses and antimicrobial medications by creating a barrier of exopolysaccharide that is difficult for the immune system and antibiotics to penetrate. A biofilm consists of an exopolysaccharide matrix that is produced and secreted by certain species of bacteria. ⋯ The rapidity of biofilm growth suggests that bacteria in wounds possess the capacity of producing this shield against antibiotics and immune effector cells early in the infection process. Therefore, efforts to prevent or slow the proliferation of bacteria and biofilms should occur soon after a wound is created. Additionally, this staining technique can be used to demonstrate the ability of agents to slow biofilm growth or to interrupt formed biofilm and may be useful in future studies of chronically infected wounds.
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Randomized Controlled Trial Clinical Trial
Lidocaine iontophoresis for local anesthesia before shave biopsy.
Lidocaine iontophoresis is a method of topical anesthesia in which lidocaine is driven into the skin under the influence of electric current. ⋯ Lidocaine iontophoresis is a safe and effective method of administering topical anesthesia before shave biopsy in adult patients.
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Case Reports
Repair of a large wound of the back, post-Mohs micrographical excision, using chronic skin expansion.
Large defects not otherwise closed primarily may be closed after chronic skin expansion. ⋯ Provided that there is not a great probability of the neoplasm extending significantly deeper or wider than expected and that the skin expander is placed so as not to disturb the plane of Mohs excision, this is a useful technique to close large Mohs defects.