Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
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Comparative Study Clinical Trial
Prospective comparison between buffered 1% lidocaine-epinephrine and skin cooling in reducing the pain of local anesthetic infiltration.
Pain associated with the infiltration of local anesthesia is attributed to the acidity of the solution. Buffering with sodium bicarbonate has been used widely to reduce this affect. Growing evidence supports skin cooling (cryoanalgesia) as a measure to reduce infiltration pain. ⋯ There is no significant difference between buffered anesthetic solution (buffering) and skin cooling in reducing the pain of infiltration of 1% lidocaine - epinephrine.