Arteriosclerosis, thrombosis, and vascular biology
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Arterioscler. Thromb. Vasc. Biol. · Feb 2014
P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension.
Carbon monoxide-releasing molecules (CORMs) represent a pharmacological alternative to CO gas inhalation. Here, we questioned whether CORM-3, a well-characterized water-soluble CORM, could prevent and reverse pulmonary hypertension (PH) in chronically hypoxic mice and in smooth muscle promoter 22 serotonin transporter mice overexpressing the serotonin transporter in smooth muscle cells (SMCs). ⋯ CORM-3 inhibits pulmonary vascular remodeling via p21, which may represent a useful approach for treating PH.