Arteriosclerosis, thrombosis, and vascular biology
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Arterioscler. Thromb. Vasc. Biol. · Mar 2014
Functional analysis of two haplotypes of the human endothelial protein C receptor gene.
To confirm the effect of the endothelial protein receptor gene (PROCR) haplotypes H1 and H3 on venous thromboembolism (VTE), to study their effect on endothelial protein C receptor (EPCR) expression in human umbilical vein endothelial cells, and to investigate the functionality of H1 tagging single-nucleotide polymorphisms in an in vitro model. ⋯ These results support a protective role of PROCR H1 against VTE and an increased risk of VTE associated with the H3 haplotype.