Experimental neurology
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Experimental neurology · Jul 1984
Synaptic density in chronic animals with experimental neurofibrillary changes.
Synaptic density was quantitated in the cerebral cortex and subiculum of rabbits with experimental neurofibrillary changes. Animals were subjected to subcutaneous injection of aluminum tartrate for 90 days, and synapses stained with ethanolic phosphotungstic acid were analyzed in animals killed 100, 200, or 300 days postinjection with aluminum tartrate. ⋯ In contrast, animals killed 100 days postinjection revealed the same synaptic density as their control. The data suggest that the synaptic depopulation associated with experimental neurofibrillary changes is a gradual process, and such changes are demonstrable only long after the initial appearance of neurofibrillary changes.