Journal of pediatric hematology/oncology
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J. Pediatr. Hematol. Oncol. · Feb 1996
Comparative StudyDetection of bone lesions in Langerhans cell histiocytosis: complementary roles of scintigraphy and conventional radiography.
This research was undertaken to determine the relative sensitivity of scintigraphic and radiographic bone survey examinations in detecting bone lesions in various regions of the skeleton in patients with a histopathologic diagnosis of Langerhans cell histiocytosis (LCH). ⋯ RNSS has a greater value in detecting sites of bone involvement with LCH than reported previously. RNSS is more sensitive than XRSS in detecting histiocytic lesions in the ribs, spine and pelvis and less sensitive in identifying lesions in the skull.
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J. Pediatr. Hematol. Oncol. · Feb 1996
Newborn screening for sickle cell disease: 4 years of experience from California's newborn screening program.
In this article we describe the success of a unique newborn screening program for sickle cell disease and other hemoglobinopathies. We will present and discuss 4 years of experience from the California Newborn Hemoglobinopathy Screening Program. ⋯ The prevalence and ethnicity data presented here demonstrate the ineffectiveness of targeted screening and justify universal screening. Had targeted screening been performed in California during the past 4 years, 58 nonblack infants with sickle cell disease would have gone undiagnosed, and 6,921 nonblack infants with sickle cell trait would not have been identified.